Continuous-Flow Microfluidic Extraction Optimization

Design and construct a multi-stage microfluidic extraction manifold that achieves a >90% partition coefficient for a surrogate solute between immiscible aqueous and organic phases. You must demonstrate steady-state performance while characterizing the mass transfer resistance across the liquid-liquid interface under varying laminar flow velocities. Please provide a rigorous analysis of your residence time distribution (RTD) and its impact on your overall extraction efficiency.